Tag: female reproductive health

– Ovulatory disorders resulting from hypothalamic-pituitary-ovarian (HPO) axis dysfunction account for 25% of infertility diagnoses.
– The HPO Axis is a synchronized network of communications between the hypothalamus, the pituitary gland, and the ovaries that regulates reproductive processes.
– Ovulatory disorders manifest as abnormal, irregular, or absent ovulation and are a leading cause of infertility.
– The WHO has classified ovulatory disorders resulting from HPO dysfunction into three groups: Hypothalamic Pituitary Failure (HPF), Eugonadal Ovulatory Dysfunction, and Hypergonadotropic Ovulatory Dysfunction.

Conditions causing HPO axis dysfunction:

Group 1: Hypothalamic Pituitary Failure (HPF)
– Idiopathic hypogonadotropic hypogonadism (IHH)
– Conditions affecting the hypothalamus or pituitary gland: gene mutations, acquired panhypopituitarism, intracranial tumors, brain radiation therapy, Langerhans cell histiocytosis, De Morsier syndrome.

Group 2: Eugonadal Ovulatory Dysfunction
– Polycystic ovary syndrome (PCOS)
– Obesity
– Hyperprolactinemia
– Primary hypothyroidism

Group 3: Primary Ovarian Insufficiency or Failure (POI/POF)
– Turner Syndrome
– FMR1 gene mutation
– Autoimmune thyroiditis
– Autoimmune polyglandular syndromes
– Environmental toxins
– Cancer treatment
– Menopause

Symptoms of HPO axis dysfunction:
– Delayed puberty
– Amenorrhea
– Infertility
– Signs of hypothyroidism
– PCOS symptoms
– Insulin resistance
– Central obesity
– Hyperprolactinemia symptoms
– Symptoms of Turner Syndrome

Laboratory tests to evaluate HPO axis dysfunction:
– Dutch Cycling Mapping Test (dry urine test)
– Vibrant America’s Sex Hormones panel (blood test)
– Anti-Mullerian Hormone (AMH) test (blood test)
– Complete thyroid panels

Treatment for HPO axis dysfunction:
– Addressing the root cause
– Nutrition: fertility-based diet, calorie increase
– Herbs and supplements: Vitex, Tribulus
– Lifestyle changes: sleep, acupuncture

Note: The article briefly mentions the GnRH stimulation test as a conventional medicine test, but does not provide further details. The article also mentions genetic testing in specific cases.

Continue Reading